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Source: http://dstonogov.livejournal.com/331227.html

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Egypt approves constitution drafted by Mursi allies

CAIRO (Reuters) - Egyptian voters overwhelmingly approved a constitution drafted by President Mohamed Mursi's allies, results announced on Tuesday showed, proving that liberals, leftists and Christians have been powerless to halt the march of Islamists in power.

Final elections commission figures showed the constitution adopted with 63.8 percent of the vote in the referendum held over two days this month, giving Mursi's Islamists their third straight electoral victory since veteran autocrat Hosni Mubarak was toppled in a 2011 revolution.

Opposition groups had taken to the streets to block what they see as a move to ram through a charter that mixes politics and religion dangerously and ignores the rights of minorities.

Mursi says the text - Egypt's first constitution since Mubarak's fall - offers enough protection for minorities, and adopting it quickly is necessary to end two years of turmoil and political uncertainty that has wrecked the economy.

"I hope all national powers will now start working together now to build a new Egypt," Murad Ali, a senior official in the Muslim Brotherhood's Freedom and Justice Party, told Reuters.

"I see this as the best constitution in Egypt's history."

In a sign that weeks of unrest have taken a further toll on the economy, the government ordered new restrictions on foreign currency apparently designed to prevent capital flight. Leaving or entering with more than $10,000 cash is now banned.

Two years since waves of unrest broke out across the Middle East and North Africa - sweeping away long-entrenched rulers in Tunisia, Libya and Yemen as well as Egypt - well-organized Islamist parties have emerged as the main beneficiaries.

Urban secularists and liberals who were behind the revolts complain that their success has been hijacked.

"We need a better constitution," said Khaled Dawood, an opposition spokesman. "It does not represent all Egyptians."

Mursi's opponents say the new constitution could allow clerics to intervene in lawmaking, while offering scant protections to minorities and women. Mursi dismisses those criticisms, and many Egyptians are fed up with street protest movements that have prevented a return to normality.

Immediately after the announcement, a small group of protesters set tires on fire and blocked traffic near the central Tahrir square, the cradle of Egypt's uprising, but there were no immediate signs of violence or major demonstrations.

Washington, which provides billions of dollars a year in military and other support for Egypt and regards it as a pillar of security in the Middle East, called on Egyptian politicians to bridge divisions and on all sides to reject violence.

"President Mursi, as the democratically elected leader of Egypt, has a special responsibility to move forward in a way that recognizes the urgent need to bridge divisions," State Department spokesman Patrick Ventrell said. He noted that many Egyptians had voiced "significant concerns" over the constitutional process.

WORSENING ECONOMY

The government says its opponents are worsening the economic crisis by prolonging political upheaval. It has pledged to impose unpopular tax increases and spending cuts to win a loan package from the International Monetary Fund.

The ban on travelling with more than $10,000 in cash followed a pledge by the central bank to take unspecified measures to protect Egyptian banks. Some Egyptians have begun withdrawing their savings in fear of more restrictions.

"I am not going to put any more money in the bank and neither will many of the people I know," said Ayman Osama, father of two young children.

He said he had taken out the equivalent of about $16,000 from his account this week and planned to withdraw more, adding that he had also told his wife to buy more gold jewellery.

The "yes" vote paves the way for a parliamentary election in about two months, setting the stage for another battle between surging Islamists and their fractious opponents.

The final result, announced by the election commission, matched - to the last decimal place - an earlier unofficial tally announced by Mursi's Muslim Brotherhood.

But the opposition said it was disappointed - it had appealed for the result to be amended to reflect what it described as major vote violations during the two-round vote.

Officials said there were no violations serious enough to change the result significantly. "We have seriously investigated all the complaints," said judge Samir Abu el-Matti of the Supreme Election Committee. The final turnout was 32.9 percent.

SENSE OF CRISIS

The referendum has sharpened painful divisions in the Arab world's most populous nation and a growing atmosphere of crisis has gripped Egypt's polarized society.

Anxiety about the economy deepened this week when Standard and Poor's cut Egypt's long-term credit rating. Prime Minister Hisham Kandil told the nation of 83 million on Tuesday the government was committed to fixing the economy.

"The main goals that the government is working towards now is plugging the budget deficit, and working on increasing growth to boost employment rates, curb inflation, and increase the competitiveness of Egyptian exports," he said.

The referendum follows Islamist victories in parliamentary and presidential elections, representing a decisive shift in a country at the heart of the Arab world where Mursi's Muslim Brotherhood was suppressed for generations by military rulers.

However, secularist and liberal opposition members hope they can organize better in time for the next parliamentary vote.

Hossam El-Din Ali, a 35-year-old newspaper vendor in central Cairo, said he agreed the new constitution would help bring some political stability but like many others he feared the possible economic austerity measures lying ahead.

"People don't want higher prices. People are upset about this," he said. "There is recession, things are not moving. But I am wishing for the best, God willing."

(Additional reporting by Patrick Werr, Tamim Elyan, Ahmed Tolba and Marwa Awad; Writing by Maria Golovnina)

Source: http://news.yahoo.com/egyptians-fret-over-economy-rancorous-vote-constitution-125308309.html

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Insurance Scare Tactics

One of the most ill-advised promises President Obama made during the health care reform debate was this: ?If you like your health care plan, you can keep your health care plan.?

He should have known better. First, insurance companies and employers are far more in control of determining whether or not you can keep your health plan than the government. That was true before ObamaCare was passed, and it?s true today.

Second, ObamaCare will indeed mean that some health plans will no longer be available a year from now. That?s a good thing, despite what you?ll be hearing from companies that make huge profits selling inadequate coverage.

A few insurers have for years used slick brochures and sales pitches to persuade people to buy policies that will not come close to shielding them from financial ruin if they get sick or injured. ?Many people who have bought these policies undoubtedly believe they have a health plan worth keeping, especially since premiums for inadequate coverage are usually lower than premiums for real insurance. You can be certain that many of those folks will complain loudly when junk health insurance is banned in 2014 and, in so doing, become unwitting soldiers in the insurance industry?s ongoing battle to gut the consumer protections in ObamaCare.

Back to that first point for a moment. I remember shaking my head when I first heard the President assure me back in 2009 that I could keep my plan if I liked it. To deliver on that promise, the law would have to require employers and insurers to keep offering plans they want to get rid of, and that was never going to happen. A few years before I left my job in the insurance industry I was forced out of a plan I liked?a PPO?because my employer decided to stop offering PPOs to its workers and to move all of us into a high-deductible plan.

Now back to junk insurance. Starting in 2014, health insurance plans must offer a minimal level of coverage, and they cannot have sky-high deductibles and caps on covered benefits.? Big insurance companies like Aetna and Cigna are not at all happy about that because they make millions selling policies with very limited benefits that cover nothing after a paltry annual cap is reached.

To make us all want to petition Congress to change ObamaCare to allow them to keep selling these policies, insurance company executives have come up with a term to scare the bejesus out of us if they don?t get their way: premium shock.

At a meeting with Wall Street financial analysts a few days ago, Aetna CEO Mark Bertolini used that term in his warning that in some cases, premium hikes could soon be ?as high as 100 percent.?

?Premium rate shock for 2014, absent subsidies and everything else, is going to be in the neighborhood of 20 to 50 percent,? Bertolini said. ?And we?re going to see some markets?go as high as 100 percent.?

Note Bertolini excluded subsidies from his math. If he hadn?t his arithmetic wouldn?t have had the same impact.? Most people who have bought limited benefit plans are low-income individuals and families who currently can?t afford anything else. Under ObamaCare, starting in 2014 people up to 400 percent of the federal poverty level will be eligible for subsidies from the government to help them buy decent coverage.

Some background: In 2005, Aetna paid $250 million for Strategic Resources Co., a company that specializes in limited benefit plans. I found one such Aetna plan online that pays no more than $10,000 a year for inpatient hospital care and doesn?t cover pre-existing conditions during the first year of the policy. Under ObamaCare, not only will annual caps be unlawful, but insurers will also no longer be able to refuse to cover preexisting conditions.

Not to be outdone, Cigna in 2006 paid $175 million to buy Star HRG to compete with Aetna in the limited-benefits marketplace. ?Aetna and Cigna and the other companies that sell limited benefit plans want to protect those investments. That?s why they want us to worry about premium shock.

They?re also using that term?and its cousin, rate shock?to get us to go to bat for them to get Congress to allow them to continue charging their older customers five times or more than what they charge their younger policyholders.? In 2014 they won?t be able to charge older folks more than three times as much as younger people.

As part of their ?premium shock? campaign, insurance executives and their allies will remind us of Obama?s 2009 promise, and they?ll blame any rate increases a year from now on ObamaCare. Some increases are inevitable, but in return we?ll be spared from paying good money for coverage that is anything but good.

Wendell is a Senior Analyst at The Center for Public Integrity where this first appeared on 12/24/2012.

Source: http://wendellpotter.com/2012/12/insurance-scare-tactics/

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PFT: McCarthy 'hopeful'?injured Packers return

TebowGetty Images

Lost in the reports and debates regarding Tim Tebow?s Wildcat tap out is the fact that the situation sparked the latest case of ESPN-on-ESPN crime.

Actually, it was more like an ESPN Battle Royal.

It started when Rich Cimini and Jane McManus of ESPNNewYork.com jointly reported on Sunday that Tebow asked to be omitted from the Wildcat package in Week 16 because the coaching staff had skipped over him when benching Mark Sanchez.? (You know, the same way the Broncos skipped over Brady Quinn when benching Kyle Orton in 2011.)

In an effort to control the damage, Tebow provided his version of the events to Adam Schefter of ESPN.? In exchange for the exclusive scoop, Schefter obviously had no choice but to pass along Tebow?s tale as he told it, without scrutiny or skepticism or cynicism.

And Tebow didn?t say that he had asked out of the Wildcat package, necessarily putting the spirit if not the letter of the two ESPN reports at odds.

But the conflict didn?t become obvious until Schefter, Merril Hoge, and Ron Jaworski appeared on the air to discuss the situation, via USAToday.com.? Schefter started by dutifully repeated what he had reported, without comment or opinion or editorial.

Enter Jaworski and Hoge, both of whom pressed Schefter for clarity as to the notion that Tebow told coach Rex Ryan that he didn?t want to play in the Wildcat package.? Schefter reiterated the guts of his report, skipping over the most important piece of information, apparently because either Schefter didn?t ask or Tebow didn?t tell.

?To me, it smells like three-day-old fish, OK?? Hoge said of Tebow?s story, which came only from Schefter?s report.? ?I think he?s phony as a three-dollar bill.? Because at the end of the day, what have I heard?? That he will do anything at any time.? You ask me to do it, I?ll do it.? And all of a sudden now that?s unacceptable?? That?s all of a sudden, ?Now I want to play quarterback or I?m not gonna play Wildcat?? . . . ? Tim Tebow, being the teammate he says he is, accepts that.? Because he says I?ll do anything for the team.? That?s all I?ve ever heard about him.? Well I think this sound shows really what he?s about.?

Jaworski then tried to suggest that Tebow never said he wouldn?t play Wildcat quarterback, citing derisively (and with air quotes) that it?s merely been ?reported? via ?sources.?? And in so doing, jumping off the top rope and landing on the work of Cimini and McManus.

Enter Schefter, who then explained that it was a ?culmination of a full season of frustration and disappointment,? and that ?somehow it?s morphed into ?I?m taking myself out.??

Hoge then made an observation that Schefter and Jaworski arguably ignored when subtly pile-driving the reporting of their colleagues, Cimini and McManus.? ?If you are for the team and that is what you do care about,? Hoge said, ?then guess what?? Whatever that coach makes, that decision, sure you can be upset, but you still do what you can for the team.? You don?t make a rift, you don?t sit there and argue.?

Next, Jaworski revisited the question of whether Tebow said what Cimini and McManus claim he said.? ?I want Tim Tebow, if this was said, to say on Tuesday, ?I told Rex Ryan I don?t want to take the Wildcat snaps,?? Jaworski said.? ?We?ve got a lot of hearsay here.?

And in that one swing, Jaworski again questioned the veracity of his colleagues? original report and indirectly chided Schefter for not asking the obvious follow-up questions when talking to Tebow.

Either way, it should be no surprise that the implosion of Tebow?s 2012 season created chaos at the network that was devoted to covering it.

Source: http://profootballtalk.nbcsports.com/2012/12/25/mike-mccarthy-hopeful-injured-packers-can-return-this-week/related/

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Alabama terror case could hinge on relationships

FILE - This undated file booking photo provided by the Mobile County/Metro Jail shows Randy "Rasheed" Wilson. A federal judge on Monday, Dec. 17, 2012 denied bond for Wilson, a 25-year-old Mobile, Ala., native charged with plotting to join violent international jihad. U.S. Magistrate Judge Katherine Nelson said Wilson should remain in jail pending further court proceedings. (AP Photo/Mobile County/Metro Jail via AL.com, File)

FILE - This undated file booking photo provided by the Mobile County/Metro Jail shows Randy "Rasheed" Wilson. A federal judge on Monday, Dec. 17, 2012 denied bond for Wilson, a 25-year-old Mobile, Ala., native charged with plotting to join violent international jihad. U.S. Magistrate Judge Katherine Nelson said Wilson should remain in jail pending further court proceedings. (AP Photo/Mobile County/Metro Jail via AL.com, File)

(AP) ? The terrorism case against an Alabama man accused of planning to wage violent jihad in Africa may hinge on just how well he knew a man on the FBI's most-wanted terrorist list.

Federal prosecutors portrayed Randy Wilson as an Islamic radical who wanted to reunite with Omar Hammami, an American who also grew up in Alabama but has since become one of the most well-known jihadists in Somalia. Wilson and another American who lived in Alabama for the last year, Mohammad Abdul Rahman Abukhdair, are accused of plotting to leave the country to join Islamic radicals fighting in North Africa.

The two men were arrested separately about two weeks ago in Georgia. Abukhdair was taken into custody at a bus station; Wilson was arrested as he was about to board a flight to Morocco.

Wilson's attorney has described him as a devout Muslim who was taking his family to Mauritania to study Islam, not wage jihad. Public defender Domingo Soto also said Wilson didn't live with Hammami, 28, about a decade ago, as the FBI has said, and the attorney questioned how well the two knew each other.

FBI agent Tim Green confirmed in federal court earlier this month that the information in the charging affidavit that Wilson and Hammami were roommates was incorrect and he wasn't sure where it came from.

It wasn't clear whether Abukhdair has an attorney yet.

Wilson, 25, has a wife and two young children. He was known around his neighborhood in Mobile, along the Alabama coast, for his big yard sales. He was friendly and outgoing, neighbors said.

Court documents, interviews with acquaintances and a sworn statement by an FBI investigator paint a picture of Wilson's troubled childhood.

Debra Lynn Weaver and Randy Lamar Wilson married in Mobile in 1986 and had Randy Jr. nine months later. Wilson's father was arrested on drug charges in the first of a string of scrapes with the law, and his mother filed for divorce four months later, when he was 1.

Wilson's mother remarried an Egyptian man when he was 5. She converted to Islam with the marriage, and her son eventually became Muslim, too.

Ashfaq Taufique, president of the Birmingham Islamic Society, remembered first meeting Wilson when he was attending an Islamic school.

"I knew him as a Muslim as a young boy," said Taufique. "He went by Randy and Rasheed."

Soto said Wilson client has never been in trouble. While attending a Muslim school in Birmingham, he was offered prestigious scholarships to study abroad at places including Saudi Arabia, Soto said.

Shortly after the Sept. 11 terrorist attacks, he became roommates with Hammami, who was the president of the Muslim Student Association at the University of South Alabama, the FBI said.

He was quoted in a campus newspaper talking about the attacks.

"Everyone was really shocked. Even now it's difficult to believe a Muslim could have done this," he told The Vanguard.

Hammami later wrote in an online autobiography that he already had turned toward radicalism by that time and privately praised Allah for the attacks.

Hammami later went to Egypt and joined Islamic insurgents, becoming a spokesman in videos and blogs.

He has since fallen out of favor with leaders of the Somalian terror group al-Shabab, which issued a statement recently distancing itself from Hammami, whom it accused of "a narcissistic pursuit of fame."

In 2010, Wilson met Abukhdair online, according to the FBI. A native of Syracuse, N.Y., Abukhdair moved to Egypt in February 2007 to study Arabic, the FBI said. He was among a group of people arrested in Egypt in 2010, on suspicion of being involved with a terror group there.

He was put in prison for two months, and then he was deported to the U.S. last year.

He lived in South Carolina and Ohio, before coming to Mobile in late October 2011 according to an FBI agent's sworn statement.

Agents already were watching Abukhdair and Wilson by then. The FBI said Abukhdair moved in with Wilson's family and gave the Friday sermon at a mosque in Mobile about a year ago.

Leaders at the mosque didn't return telephone calls seeking comment, and a worker shooed away a reporter who visited.

The FBI said it kept tabs on the pair through an undercover operative. Wilson "described Hammami as a friend and showed the (undercover operative) an al-Qaeda video on his laptop praising jihad and the downfall of the West," the FBI said.

Wilson and Abukhdair began concocting ways to travel to Africa to join in jihad, an agent wrote.

Wilson, the FBI said, believed he would receive "special treatment" in Somalia because of his connection with Hammami.

"In addition to travel plans, they discussed their joy that Omar Hammami is now on the FBI 'Most Wanted Terrorists' list, and were excited that he is now even more famous," said the FBI statement.

Wilson lived next door to Tom Rothaar for two years. Rothaar said he was a friendly neighbor and who would have frequent yard sales with items he bought in bulk from big-box retail stores.

Rothaar said he was "staggered" by Wilson's arrest and tried to make sense of it during a 5-mile run.

"I couldn't," Rothaar said. "The only thing I can think is all the typical clich?s about how I cannot believe he was living next door and seemed so normal."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-12-23-Terror%20Charges-Alabama/id-355ef6e9b7404248af796a56024245f1

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Holiday music stops at Irving Berlin's NY door

(AP) ? A caroling group that for 35 years has performed the Irving Berlin classic "White Christmas" on Christmas Eve outside the New York City home where he lived has cancelled the tradition.

A group spokesman says the plans were abruptly cancelled last week for lack of space at the Manhattan home, which now serves as the Luxembourg consulate.

The tradition started in the late 1970s with one cabaret singer outside the home. In 1983, Berlin invited the singers inside for cocoa and cookies.

Berlin died in 1989 at age 99.

Luxembourg Consul-General Jean-Claude Knebeler tells the New York Post the ballroom where the group performed is filled with office equipment because the consulate expanded. He says he hopes the tradition resumes in another year in the consulate's library.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-12-24-Irving%20Berlin-Carolers/id-9a4e28d1e344425395dc40f38b2c264d

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5 Benefits of Intense Exercise on Anxiety | 4E Fitness

5 Benefits of Intense Exercise on Anxiety

One of the main factors standing in the way of good fitness is this idea that exercise is only for your physical health. Those considering some type of fitness regimen often put it off because they don?t feel they?re in a hurry to improve their physical health. They know they need to lose weight, and they know that exercise is important for their heart health, but they don?t otherwise feel that they need to rush, especially since exercise can be so tough in the beginning.

But the truth is that exercise is profoundly beneficial for your mental health as well ? especially anxiety. Those living with anxiety regularly need to make sure they?re exercising as often as possible, because the reality is that exercise ? and a lack thereof ? can have serious effects on how you deal with stress.

Benefits of Intense Exercise

The intensity of exercise does matter. Any and all exercise is beneficial, and even if you decide you can?t handle intense exercise you do need to stay as active as possible. But intense exercise has many benefits for those living with anxiety. These include:

Most people have heard of a ?runner?s high? but few people know what it is. A runner?s high is when your brain releases neurotransmitters known as ?endorphins? in an effort to control pain. But those same endorphins also improve mood as well. They genuinely affect your brain chemistry in such a way that you?ll have more positive thoughts and feelings, and they?re a great tool for controlling your anxiety.

Exercise also burns cortisol. Cortisol is a hormone released during stress that is responsible for many anxiety symptoms, especially mental symptoms. Exercise doesn?t burn cortisol completely, but it can cut down on the stress hormone dramatically.

Anxiety also represents a constant surge of adrenaline, which causes things like rapid heartbeat and tense muscles. Exercise ? especially intense exercise ? burns that adrenaline away, ultimately providing your body with relief that it was unable to get previously.

Tense muscles genuinely create a tense mind. That?s why when you?re inactive, your anxiety increases, because your muscles have tons of extra energy that ends up turning into anxiety. Exercise tires the muscles dramatically. Once your muscles are tired, it not only reduces physical symptoms (due to tired muscles) ? it also reduces mental anxiety as a result of the mind/body connection.

  • Healthy Time Consumption Strategy

Many people don?t realize this, but a part of managing anxiety is simply passing time as anxiety free as possible. The more time spent without anxiety, the easier it is to control it. Exercising regularly provides you with that time ? a break from the business of the world in a way that is mentally and physically healthy.

The Effects of Exercise on Anxiety

These benefits are not some new age alternative treatment either. The benefits of exercise on anxiety are extremely well-researched, and some doctors claim that exercise may be as OR more valuable than anxiety medications (although possibly for less time). Intense anxiety is incredibly powerful.

Reducing anxiety is not just about going to a doctor and seeing what medicines they can give you, or even going to therapy (though you should still strongly consider therapy as well). It?s also about making lifestyle changes that benefit your ability to cope with stress. Intense exercise can be extremely powerful as an anxiety management tool, and while it may not cure your anxiety completely, it can cut down on your anxiety dramatically.

About the Author: Ryan Rivera exercises every day as a way of fighting off his anxiety. He runs a website about anxiety which can be found at www.calmclinic.com.

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Source: http://www.4everfitlife.com/5-benefits-of-intense-exercise-on-anxiety/

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Why Boehner Needs House Democrats

With the spectacular and very public failure of a Thursday night vote to let the Bush-era tax cuts expire for millionaires, House Speaker John Boehner now faces a certain truth: any fiscal cliff deal he cuts will rely on Democratic votes.

It was always likely that Boehner was going to pick up some Democratic support if the deal included a de facto tax increase on the wealthiest Americans and the president supported it. The big question facing Boehner now is just how many Democrats he will need, and whether he can bring a bill to the floor that does not even have majority support from his own caucus.

Boehner did not rule out that possibility Friday and while he said he was proud of the conference for sticking by its principles, he disagrees, a sign he is not given up hope for a getting a deal.

"There was a perception created that that vote last night was going to increase?taxes. Now I disagree with that -- with that characterization of the bill, but that impression was out there. Now, we had a number of our members who just really didn't want to be perceived as having raised taxes," Boehner said.

Risks to Boehner's speakership be damned, Democratic leaders are anticipating they may have to join him in large numbers to pass a bill.

?There?s no rule preventing him from allowing the entire House to work its will, Democrats and Republicans together, and that may mean that we have to pass something that does not have 50 percent of Republicans on board,? Rep. Chris Van Hollen, D-Md., the ranking Democrat on the House Budget Committee, told National Journal.

Van Hollen said the only question that remains is whether a deal gets struck now or within the first two weeks of the New Year ? meaning the door is open to cutting a deal after the leadership election, which could be a saving grace for Boehner. But, Van Hollen added, ?I think we should do it immediately.? He declined to delve into the prospect of working with a Republican other than Boehner at the helm of the House.

One GOP member, who spoke on the condition of anonymity so he could speak openly, predicted the country "would go through the cliff, [President Obama] will figure out what deal he can cut, it'll go through the Senate and we'll have to pass it out," he said.?

That may force Pelosi and Boehner to collaborate, a task for which they have shown little appetite up until now. In an encouraging sign, they had a short meeting in the corridors of the Capitol today as they left the House floor after a pro-forma session.

?Neither one is going to want to force more colleagues than is absolutely necessary to support it,? said Steven Smith, a political science professor at Washington University in St. Louis. ?Both sets of leaders will have their reputations on the line and it?ll be interesting to see how that works out.?

While Boehner is taking his lumps now in the media, there was a strategy at work, designed to gauge what the Republican conference could stomach. It's too early to say if the gambit will pay off, but Boehner has an idea of where his members stand now.

"I think what they were doing here with Plan B was a vote-counting operation. Intelligence gathering," said John Feehery, a one-time aide to former Speaker Dennis Hastert.

Hastert said he was puzzled by Boehner's strategy and said his own greatest successes came when he worked behind the scenes.?

"I don't know what his game is. ? John is doing what he thinks he has to do," Hastert said in an interview.

Pelosi has been publicly urging Boehner to cut a deal, saying that the job they have both held requires sacrifice and tough votes. Last week, she likened the fiscal cliff deal to a vote to fund the Iraq War she brought to the floor in 2007 as a newly elected speaker. To gain the support of her caucus, she had to separate the war funding measures from the rest of domestic spending so that many Democrats, herself included, could vote against it (the measure passed with Republican support).

?Do you know what it was like for me to bring a bill to the floor to fund the war in Iraq, a war predicated on a misrepresentation to the American people?" Pelosi said, adding that some members have still not forgiven her.

?So it's tough, but you have to do it,? said Brendan Daly, Minority Leader Nancy Pelosi's former communications director,?who now works at Ogilvy Public Relations.?Ultimately, he said, it did not damage her speakership.

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Source: http://news.yahoo.com/why-boehner-needs-house-democrats-060003261--politics.html

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First goat genome sets a good example for facilitating de novo assembly of large genomes

Dec. 23, 2012 ? In a collaborative study published online today in Nature Biotechnology, researchers from Kunming Institute of Zoology, Chinese Academy of Sciences, BGI, and other institutes, have completed the first genome sequence of domestic goat by a robust approach integrated with next-generation sequencing (NGS) and whole-genome mapping (WGM) technologies. The goat genome is the first reference genome for small ruminant animals and may help to advance the understanding of distinct ruminants' genomic features from non-ruminant species. This work also yields a valuable experience for facilitating the de novo assemblies of large, complex genomes in the future.

Goats are recognized as an important member of the world livestock industry, and with many unique biological features. They are an important economic resource in many developing countries around the world, especially in China and India. However, despite their agricultural and biological importance, breeding and genetic studies of goats have been hampered by the lack of a high quality reference genome sequence. The goat genome sequence will be useful for facilitating the identification of SNP markers for marker-assisted breeding, and improving the utility of the goat as a biomedical model and bioreactor.

With the availability of next-generation sequencing (NGS), draft assemblies are easy to generate nowadays. However, to finish a sequence to the chromosome level remains a hard nut to crack. In this study, the results show that a single NGS platform, when combined with whole-genome mapping technology, could produce a finished assembly much faster and with high quality than other currently available mapping strategies such as BACs or FISH. Through this integrated approach, researchers obtained the ~2.66 Gb goat reference genome from a female Yunnan black goat.

Transposable elements (TEs) are major components of mammalian genomes and contribute to gene and/or genome evolution. The TEs in goat genome are similar to those of cattle, and contain large numbers of ruminant-specific repeats, such as SINE-tRNA and SINE-BovA. It is reported that SINE-BovA repeat expanded primarily in the cattle genome. However, in this study, researchers found the SINE-tRNA repeat expanded specifically in the goat genome.

Through constructing a phylogenetic tree among goats, cattle, horses, dogs, opossums and humans, researchers found the goat shared a common ancestor with cattle about 23 million years ago. Further comparison analysis revealed 44 rapidly evolving genes under positive selection, seven of which are immune-related genes and three are pituitary hormone or related genes. The immune-related genes identified also exist in cattle. The findings suggest that the rapid evolution of pituitary hormones may be related to the different features between goat and cattle in milk production, development rates of the fetus and/or hair variation.

The major histocompatibility complex (MHC) plays an important role in the immune system. In this study, the goat MHC was found to be located on chromosome 23 and contains two regions with length of 2.25 Mb and 360 kb, respectively. With the high quality genome assembly, further understanding of the goat MHC will be useful for immunological studies and vaccine development.

One of the distinguishing characteristics of mammals is the protective growth known as hair. It is produced by hair follicles within the skin, which could provide either protection (guard hairs) or insulation (underfur). The two major hair follicles include the primary hair follicle that produces only coat hair in all mammals, and the secondary hair follicle that can produce the cashmere or "fine hair" in certain mammals, including goats and antelopes. Despite a 2,500-year history and the extent of raw cashmere production, people are lack of understanding of the molecular mechanisms of cashmere formation and development.

Researchers conducted transcriptomic analysis on the primary and secondary follicles of a cashmere goat, revealing 51 genes that are differentially expressed between the two types of hair follicles. Keratin and keratin-associated proteins are the main structural proteins of hair fibers, determining the quality of fiber together. In the study, 29 keratin genes and 30 keratin-associated protein genes were detected in both types of follicles. Interestingly, they found two keratin genes and ten keratin-associated protein genes were consistently differentially expressed between primary and secondary hair follicles, suggesting that the keratin-associated protein genes may be more important in determining the structure of cashmere fibers. In addition to the keratin genes and keratin-associated protein genes, researchers also found several enzymes of amino acid biosynthesis, with implications in regulating primary hair growth and hair cycle.

Xun Xu, Deputy Director of BGI, said, "The goat reference genome is an important stepping stone in the molecular breeding of cashmere goats, and will help to advance the comparative studies on ruminants. The transcriptomic analysis on the primary and secondary follicles will open a new way for better improving the quality cashmere wool."

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The above story is reprinted from materials provided by BGI Shenzhen, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yang Dong, Min Xie, Yu Jiang, Nianqing Xiao, Xiaoyong Du, Wenguang Zhang, Gwenola Tosser-Klopp, Jinhuan Wang, Shuang Yang, Jie Liang, Wenbin Chen, Jing Chen, Peng Zeng, Yong Hou, Chao Bian, Shengkai Pan, Yuxiang Li, Xin Liu, Wenliang Wang, Bertrand Servin, Brian Sayre, Bin Zhu, Deacon Sweeney, Rich Moore, Wenhui Nie, Yongyi Shen, Ruoping Zhao, Guojie Zhang, Jinquan Li, Thomas Faraut, James Womack, Yaping Zhang, James Kijas, Noelle Cockett, Xun Xu, Shuhong Zhao, Jun Wang, Wen Wang. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nature Biotechnology, 2012; DOI: 10.1038/nbt.2478

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/CNn97tXK9DU/121223152629.htm

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